The Israeli IPMN clinical program
Led by Hadassah University Hospital & The Hebrew University of Jerusalem. The aim of the project is to predict the malignancy potential of IPMN.
Research Modules
For each aspect of the disease, a research module will be constructed, using artificial intelligence (AI) which will yield a prediction algorithm. The various algorithms will be integrated into a patient's digital file in a way that allows easy access to patients’ data. The digital portfolio will also serve as a unified predictive model that integrates the various algorithms. The various modules are listed below:
RESEARCH PROGRAM MODULES:
Clinical Module
The purpose of this module is to integrate patients' data including demographic and clinical data, laboratory test results, radiological data from MRI / MRCP tests and pathological data from IPMN samples (cyst fluid or tissue sample). This module will also include
RESEARCHERS
Dr. Lior Katz, MD PhD
Lior Katz received his MD from the Hebrew University of Jerusalem, and his master’s degree in health administration from Ben-Gurion University, with supreme excellence. He did his fellowship in gastroenterology at the Sheba Medical Center, and his postdoctoral
Radiological Module
The purpose of this module is to test the power of imaging variables based on MRI scans to predict pancreatic malignancy from IPMN. The variables will be volumetric and will include the total volume of the cysts, the volume of the largest cysts and
RESEARCHERS
Professor Jacob Sosna, MD PhD
Professor Jacob Sosna earned his MD from the Sackler Faculty of Medicine of Tel Aviv University with Distinction. He completed his residency in Radiology at Hadassah Medical Center in Jerusalem, Israel in 2001. He traveled to Boston to the Beth Israel Deaconess
Pathological Module
The purpose of this module is to create a model that will predict the risk of developing a malignant pancreatic lesion from IPMN based on pathological findings. A method will be developed, using digital pathology based AI to study visual pathological
RESEARCHERS
Professor Eli Pikarsky, MD PhD
Dr. Nir Pillar, MD PhD
Eli Pikarsky received his MD and PhD from the Hebrew University of Jerusalem. He is a professor of pathology at the Lautenberg center for Immunology and Cancer Research at the Hebrew University Medical School and the chairman of the department
Dr. Nir Pillar is currently a pathologist at Hadassah Medical Center, Jerusalem, Israel. He received his MD from Ben-Gurion University of the Negev, and later started his training as a medical oncologist at Sheba Medical Center. After two years, Dr. Pillar decided to
Molecular pathology module
In a previous study published by our group (Nat Commun. 2020 Sep 9; 11 (1): 4516) on the process of progression of pancreatic cancer from normal tissue through pancreatic intraepithelial neoplasia (PanIN), it was found that PanINs are composed of
RESEARCHERS
Dr. Oren Parnas, MD PhD
Dr. Oren Parnas is an Assistant Professor at the immunology and cancer research department, in the school of medicine at the Hebrew University of Jerusalem. Oren performs B.Sc.degree in industrial and management engineering, at the Technion and
Liquid biopsy module
Based on pancreatic methylation markers in plasma-free DNA (cfDNA),It was found that in approximately 50% of pancreatic cancer cases, a signal above the basal level can be detected. We will construct a test consisting of 10 independent methylation
RESEARCHERS
Professor Yuval Dor, MD PhD
Yuval Dor, PhD, is a professor of biology at the Hebrew University-Hadassah Medical School. He earned his PhD in vascular biology at the Hebrew University in 2001 with Prof. Eli Keshet, and trained as a post-doc at Harvard University with Doug Melton until 2004.
Genetically module
In this module genomic data of both the patient using Whole Genome Sequencing (WGS) and the IPMN by genomic sequencing of the cyst cells will be examined. WGS will allow the detection of germline mutations with a predisposition to IPMN as well as
RESEARCHERS
Dr. Naama Elefant, MD PhD
Dr. Lior Katz, MD PhD
Dr. Elefant is a fellow in clinical genetics at Hadassah Medical Center. She holds a BSc with honours in computer science and computational biology and an MD/PhD, both from the Hebrew University. She conducted her PhD studies in the lab of Prof. Hanah
Lior Katz received his MD from the Hebrew University of Jerusalem, and his master’s degree in health administration from Ben-Gurion University, with supreme excellence. He did his fellowship in gastroenterology at the Sheba Medical Center, and his postdoctoral
Oral microbiome module
The presence of the bacterium Porphyromonas gingivalis in the oral cavity as a result of a periodontal disease is known to be associated with the development of pancreatic cancer. The purpose of this module is to characterize the oral microbiome in
RESEARCHERS
Professor Gabriel Nussbaum, MD PhD
Dr. Gabriel Nussbaum is an Associate Professor in, and the current head of the Institute of Dental Sciences of the Hebrew University of Jerusalem in Israel. He earned his MD and PhD from the Albert Einstein School of Medicine and completed an internal medicine
Senescence and inflammatory markers module
This module will test the existence of senescent cells in IPMN as already demonstrated in PanIN. This cell population has a unique profile of inflammatory cytokine secretion (SASP) and has been found to express COX2. Inhibition of this enzyme by NSAIDS and
RESEARCHERS
Professor Ittai Ben- Porath, MD PhD
Ittai Ben-Porath is an Associate Professor at the Hebrew University Faculty of Medicine, which he joined in 2007. He obtained his Ph.D. at the Hebrew University, and performed postdoctoral research under the instruction of Dr. Robert A. Weinberg at the